An irregular pupil

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Multiple Choice

An irregular pupil

Explanation:
An irregular pupil points to an iris or ocular development abnormality, most commonly coloboma. Coloboma arises when the embryonic fissure fails to close during early eye development, leaving a notch in the iris that creates a notched or “keyhole” pupil appearance. This explains the irregular pupil seen clinically. The other conditions involve different systems and do not present with a distorted pupil: conjunctivitis causes red eye with discharge and irritation; carpal tunnel syndrome produces numbness and tingling in the hand; calf atrophy shows muscle wasting in the leg. Thus the irregular pupil most specifically fits iris/eye development abnormality—coloboma.

An irregular pupil points to an iris or ocular development abnormality, most commonly coloboma. Coloboma arises when the embryonic fissure fails to close during early eye development, leaving a notch in the iris that creates a notched or “keyhole” pupil appearance. This explains the irregular pupil seen clinically.

The other conditions involve different systems and do not present with a distorted pupil: conjunctivitis causes red eye with discharge and irritation; carpal tunnel syndrome produces numbness and tingling in the hand; calf atrophy shows muscle wasting in the leg. Thus the irregular pupil most specifically fits iris/eye development abnormality—coloboma.

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